How Much Can A Medical Family History Be Overcome?

Just a curious guy by nature.Doing some reading and wondering how much people’s medical family history can be overcome by minimizing controllable risk factors?
You hear of families with histories of serious illnesses, realizing that genetics can be a frightening thing. So in some families are people almost assuredly handed an early death sentence, even with a highly healthy lifestyle or can someone make a family history nearly irrelevant?

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